Difference in the Inhibitory Effect of Thiol Compounds and Demetallation Rates from the Zn(II) Active Site of Metallo-β-lactamases (IMP-1 and IMP-6) Associated with a Single Amino Acid Substitution

Author:

Yamaguchi Yoshihiro123,Kato Koichi456ORCID,Ichimaru Yoshimi46,Uenosono Yuya2,Tawara Sakiko2,Ito Rio2,Matsuse Natsuki3,Wachino Jun-ichi7,Toma-Fukai Sachiko8,Jin Wanchun4,Arakawa Yoshichika9,Otsuka Masami1011ORCID,Fujita Mikako10,Fukuishi Nobuyuki4,Sugiura Kirara4,Imai Masanori4,Kurosaki Hiromasa4

Affiliation:

1. Environmental Safety Center, Kumamoto University, 39-1 Kurokami 2-Chome, Chuo-ku, Kumamoto860-8555, Japan

2. Graduate School of Science and Technology, Kumamoto University, 39-1 Kurokami 2-Chome, Chuo-ku, Kumamoto860-8555, Japan

3. Faculty of Engineering, Kumamoto University, 39-1 Kurokami 2-Chome, Chuo-ku, Kumamoto860-8555, Japan

4. College of Pharmacy, Kinjo Gakuin University, 2-1723 Omori, Moriyama-ku, Nagoya, Aichi463-8521, Japan

5. Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya, Aichi468-8503, Japan

6. Faculty of Pharmaceutical Sciences, Shonan University of Medical Sciences, 16-48, Kamishinano, Totsuka-ku, Yokohama, Kanagawa244-0806, Japan

7. Department of Medical Technology, Faculty of Medical Sciences, Shubun University, 6 Nikko-cho, Ichinomiya, Aichi491-0938, Japan

8. Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama-cho, Ikoma, Nara630-0192, Japan

9. Department of Bacteriology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi466-8550, Japan

10. Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto862-0973, Japan

11. Department of Drug Discovery, Science Farm Ltd., 1-7-30 Kuhonji, Chuo-ku, Kumamoto862-0976, Japan

Funder

Kinjo Gakuin University

Daiko Foundation

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

Reference89 articles.

1. Emergence of Global Antibiotic Resistance

2. Antimicrobial Resistance: a One Health Perspective

3. World Health Organization (WHO). Antimicrobial resistance; WHO: Geneva, Switzerland, 2021https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance (accessed July, 2022).

4. Centers for Disease Congrol and Prevation (CDC). Antibiotic/Antimicrobal resistance; CDC: Atlanta, GAhttps://www.cdc.gov/drugresistance/index.html (accessed July, 2022).

5. Antibiotic resistance threats in the United States, 2019

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