2-Aminothiazole-4-carboxamides Enhance Readthrough of Premature Termination Codons by Aminoglycosides-Reference-Cited by-同舟云学术

2-Aminothiazole-4-carboxamides Enhance Readthrough of Premature Termination Codons by Aminoglycosides

Published:2019-04-09 Issue:5 Volume:10 Page:726-731
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Rabea Safwat M.¹,Baradaran-Heravi Alireza²,Balgi Aruna D.²,Krause Alexandra²,Hosseini Farahabadi Sara²,Roberge Michel²,Grierson David S.¹^ORCID

Affiliation:

1. Faculty of Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, Vancouver, British Columbia V6T 1Z3, Canada

2. Department of Biochemistry and Molecular Biology, University of British Columbia, 2350 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada

Funder

Canadian Cancer Society Research Institute

Genome British Columbia

Mitacs

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.8b00610

Reference26 articles.

1. A meta-analysis of nonsense mutations causing human genetic disease

2. Structural basis for the inhibition of the eukaryotic ribosome

3. Targeting Nonsense Mutations in Diseases with Translational Read-Through-Inducing Drugs (TRIDs)

4. Characterization of new-generation aminoglycoside promoting premature termination codon readthrough in cancer cells

5. Synthetic Aminoglycosides Efficiently Suppress Cystic Fibrosis Transmembrane Conductance Regulator Nonsense Mutations and Are Enhanced by Ivacaftor

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