Saccharin Aza Bioisosteres—Synthesis and Preclinical Property Comparisons-Reference-Cited by-同舟云学术

Saccharin Aza Bioisosteres—Synthesis and Preclinical Property Comparisons

Published:2017-05-08 Issue:6 Volume:8 Page:672-677
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Chen Yantao¹^ORCID,Aurell Carl-Johan²,Pettersen Anna³,Lewis Richard J.⁴,Hayes Martin A.⁵^ORCID,Lepistö Matti⁴,Jonson Anna C.⁴,Leek Hanna⁴,Thunberg Linda⁴

Affiliation:

1. Medicinal Chemistry, Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Development, AstraZeneca R&D Gothenburg, 431 83 Mölndal, Sweden

2. Large Scale Chemistry, Early Chemical Development, Pharmaceutical Sciences, AstraZeneca R&D Gothenburg, 431 83 Mölndal, Sweden

3. Pharmaceutical Technology and Development, Product Development, AstraZeneca Operations Gothenburg, 431 83 Mölndal, Sweden

4. Medicinal Chemistry, Respiratory, Inflammation and Autoimmunity, Innovative Medicines and Early Development, AstraZeneca R&D Gothenburg, 431 83 Mölndal, Sweden

5. DMPK, Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Development, AstraZeneca R&D Gothenburg, 431 83 Mölndal, Sweden

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.7b00137

Reference32 articles.

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2. Saccharin: A lead compound for structure-based drug design of carbonic anhydrase IX inhibitors

3. Saccharin Derivatives as Inhibitors of Interferon-Mediated Inflammation

4. Green approach for drug design and discovery of paracetamol analogues as potential analgesic and antipyretic agents

5. Lai, L.; Liu, Y.; He, C.; Wu, Y.; He, S.; Shang, E.Benzoisothiazole compounds as 5-LOX and mPGES-1 inhibitors and their preparation, pharmaceutical compositions and use in the treatment of inflammations. CN 103254151, Aug. 21, 2013.

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