Discovery of Tetralones as Potent and Selective Inhibitors of Acyl-CoA:Diacylglycerol Acyltransferase 1-Reference-Cited by-同舟云学术

Discovery of Tetralones as Potent and Selective Inhibitors of Acyl-CoA:Diacylglycerol Acyltransferase 1

Published:2018-01-18 Issue:2 Volume:9 Page:103-108
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Cheung Mui¹^ORCID,Tangirala Raghuram S.²,Bethi Sridhar R.²,Joshi Hemant V.²,Ariazi Jennifer L.¹,Tirunagaru Vijaya G.²,Kumar Sanjay¹

Affiliation:

1. Virtual Proof of Concept Discovery Performance Unit, Alternative Discovery and Development, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States

2. Collaborative Research, GVK Biosciences Private Limited, 28A, IDA, Nacharam, Hyderabad 500076, India

Funder

GlaxoSmithKline

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.7b00450

Reference19 articles.

1. Fatty acids, triglycerides, and glucose metabolism: recent insights from knockout mice

2. Inhibition of Triglyceride Synthesis as a Treatment Strategy for Obesity

3. Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids

4. Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat

5. Current Status of the Research and Development of Diacylglycerol O-Acyltransferase 1 (DGAT1) Inhibitors

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