Design of Selective Benzoxazepin PI3Kδ Inhibitors Through Control of Dihedral Angles-Reference-Cited by-同舟云学术

Design of Selective Benzoxazepin PI3Kδ Inhibitors Through Control of Dihedral Angles

Published:2017-08-29 Issue:9 Volume:8 Page:936-940
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Safina Brian S.¹^ORCID,Elliott Richard L.²,Forrest Andrew K.²,Heald Robert A.²,Murray Jeremy M.¹,Nonomiya Jim¹,Pang Jodie¹,Salphati Laurent¹,Seward Eileen M.²,Staben Steven T.¹,Ultsch Mark¹,Wei Binqing¹,Yang Wenqian³,Sutherlin Daniel P.¹

Affiliation:

1. Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States

2. Discovery from Charles River, 8-9 Spire Green Centre, Harlow, Essex CM 19 5TR, United Kingdom

3. ChemPartner, 998 Halei Road, Zhangjiang Hi-tech Park, Pudong New Area, Shanghai 201203, China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.7b00170

Reference15 articles.

1. Pharmacophore modeling and applications in drug discovery: challenges and recent advances

2. Applications of Fluorine in Medicinal Chemistry

3. A Survey of the Role of Noncovalent Sulfur Interactions in Drug Design

4. The Cambridge Structural Database

5. The Cambridge Structural Database: a quarter of a million crystal structures and rising

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