Evaluation of Oxetan-3-ol, Thietan-3-ol, and Derivatives Thereof as Bioisosteres of the Carboxylic Acid Functional Group-Reference-Cited by-同舟云学术

Evaluation of Oxetan-3-ol, Thietan-3-ol, and Derivatives Thereof as Bioisosteres of the Carboxylic Acid Functional Group

Published:2017-07-18 Issue:8 Volume:8 Page:864-868
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Lassalas Pierrik¹,Oukoloff Killian²,Makani Vishruti³,James Michael³,Tran Van¹,Yao Yuemang³,Huang Longchuan¹,Vijayendran Krishna¹,Monti Ludovica²,Trojanowski John Q.³,Lee Virginia M.-Y.³,Kozlowski Marisa C.¹^ORCID,Smith Amos B.¹^ORCID,Brunden Kurt R.³,Ballatore Carlo²^ORCID

Affiliation:

1. Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States

2. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States

3. Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States

Funder

National Institute on Aging

Penn Medicine, University of Pennsylvania

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.7b00212

Reference27 articles.

1. Carboxylic Acid (Bio)Isosteres in Drug Design

2. Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design