Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate Dehydrogenase-Reference-Cited by-同舟云学术

Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate Dehydrogenase

Published:2017-03-17 Issue:4 Volume:8 Page:438-442
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Maetani Micah¹²,Kato Nobutaka²,Jabor Valquiria A. P.³,Calil Felipe A.³^ORCID,Nonato Maria Cristina³,Scherer Christina A.²^ORCID,Schreiber Stuart L.¹²⁴^ORCID

Affiliation:

1. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States

2. Broad Institute, Cambridge, Massachusetts 02142, United States

3. School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo 14040-903, Brazil

4. Howard Hughes Medical Institute, Cambridge, Massachusetts 02138, United States

Funder

Howard Hughes Medical Institute

Harvard University

Division of Graduate Education

Bill and Melinda Gates Foundation

Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.7b00030

Reference24 articles.

1. WHO. World MalariaReport 2015. http://who.int/malaria/publications/world-malaria-report-2015/report/en/.

2. Artemisinin Resistance inPlasmodium falciparumMalaria

3. Recent clinical and molecular insights into emerging artemisinin resistance in Plasmodium falciparum

4. Antimalarial drug discovery — approaches and progress towards new medicines

5. Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia

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