Axial Hydrogen at C7 Position and Bumpy Tetracyclic Core Markedly Reduce Sterol’s Affinity to Amphotericin B in Membrane-Reference-Cited by-同舟云学术

Axial Hydrogen at C7 Position and Bumpy Tetracyclic Core Markedly Reduce Sterol’s Affinity to Amphotericin B in Membrane

Published:2015-01-05 Issue:2 Volume:54 Page:303-312
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Nakagawa Yasuo¹,Umegawa Yuichi¹,Nonomura Kenichi¹,Matsushita Naohiro¹,Takano Tetsuro¹,Tsuchikawa Hiroshi¹,Hanashima Shinya¹,Oishi Tohru¹,Matsumori Nobuaki¹,Murata Michio¹

Affiliation:

1. Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan

Funder

Ministry of Education, Culture, Sports, Science, and Technology

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi5012942

Reference64 articles.

1. How do the polyene macrolide antibiotics affect the cellular membrane properties?

2. Structure and Biological Activity of 8-Deoxyheronamide C from a Marine-Derived Streptomyces sp.: Heronamides Target Saturated Hydrocarbon Chains in Lipid Membranes

3. Direct and Stereospecific Interaction of Amphidinol 3 with Sterol in Lipid Bilayers

4. Membrane-permeabilizing activities of amphidinol 3, polyene-polyhydroxy antifungal from a marine dinoflagellate

5. Hairpin conformation of amphidinols possibly accounting for potent membrane permeabilizing activities

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