Secondary Amides of (R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropionic Acid as Inhibitors of Pyruvate Dehydrogenase Kinase-Reference-Cited by-同舟云学术

Secondary Amides of (R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropionic Acid as Inhibitors of Pyruvate Dehydrogenase Kinase

Published:1999-12-31 Issue:2 Volume:43 Page:236-249
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Aicher Thomas D.¹,Anderson Robert C.¹,Gao Jiaping¹,Shetty Suraj S.¹,Coppola Gary M.¹,Stanton James L.¹,Knorr Douglas C.¹,Sperbeck Donald M.¹,Brand Leonard J.¹,Vinluan Christine C.¹,Kaplan Emma L.¹,Dragland Carol J.¹,Tomaselli Hollis C.¹,Islam Amin¹,Lozito Robert J.¹,Liu Xilin¹,Maniara Wieslawa M.¹,Fillers William S.¹,DelGrande Dominick¹,Walter R. Eric¹,Mann William R.¹

Affiliation:

1. Novartis Institute for Biomedical Research, 556 Morris Avenue, Summit, New Jersey 07901

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm990358%2B

Reference75 articles.

1. Inactivation of pyruvate dehydrogenase complex in heart muscle mitochondria of gold-thioglucose-induced obese mice is not due to a stable increase in activity of pyruvate dehydrogenase kinase

2. Active and inactive forms of pyruvate dehydrogenase in rat heart and kidney: Effect of diabetes, fasting, and refeeding on pyruvate dehydrogenase interconversion

3. Effect of starvation and insulin in vivo on the activity of the pyruvate dehydrogenase complex in rat skeletal muscles