Total Synthesis of (−)-5,6-Dihydrocineromycin B

Author:

Li Guozhi1,Yang Xiaoxia1,Zhai Hongbin1

Affiliation:

1. Laboratory of Modern Synthetic Organic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China, and The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 College Road, Beijing 100083, China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Reference22 articles.

1. Cineromycins, .GAMMA.-Butyrolactones and Ansamycins by Analysis of the Secondary Metabolite Pattern Created by a Single Strain of Strepomycest.

2. bAs reported by Zeeck et al.(1a)the isolated sample of dihydrocineromycin B had an optical rotation ([α]20D) of +10 (c0.1, MeOH) corresponding to the proposed structure of1(Scheme1). In contrast, we found that the optical rotation data for the structure1had a negative sign after its total synthesis was completed (see text).

3. Total Synthesis of the Macrolide Antibiotic 5,6-Dihydrocineromycin B

4. Enantioselective total synthesis of ingramycin

5. Enantioselective total synthesis of cineromycin B

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