2-Acetylpyridine Thiosemicarbazones are Potent Iron Chelators and Antiproliferative Agents: Redox Activity, Iron Complexation and Characterization of their Antitumor Activity-Reference-Cited by-同舟云学术

2-Acetylpyridine Thiosemicarbazones are Potent Iron Chelators and Antiproliferative Agents: Redox Activity, Iron Complexation and Characterization of their Antitumor Activity

Published:2009-02-13 Issue:5 Volume:52 Page:1459-1470
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Richardson Des R.¹,Kalinowski Danuta S.¹,Richardson Vera¹,Sharpe Philip C.¹,Lovejoy David B.¹,Islam Mohammad¹,Bernhardt Paul V.¹

Affiliation:

1. Department of Pathology and Bosch Institute, University of Sydney, Sydney, New South Wales 2006, Australia, Centre for Metals in Biology, School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland 4072, Australia

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm801585u

Reference89 articles.

1. The Evolution of Iron Chelators for the Treatment of Iron Overload Disease and Cancer

2. 11 Control of disease by selective iron depletion: a novel therapeutic strategy utilizing iron chelators

3. Coordination chemistry and biology of chelators for the treatment of iron overload disorders

4. Cytotoxic iron chelators: characterization of the structure, solution chemistry and redox activity of ligands and iron complexes of the di-2-pyridyl ketone isonicotinoyl hydrazone (HPKIH) analogues

5. Dipyridyl Thiosemicarbazone Chelators with Potent and Selective Antitumor Activity Form Iron Complexes with Redox Activity

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