Development of a Scalable Process for 1-(3,5-Dichlorophenyl)-5-iodo-3-methyl- (4-methylbenzyl)-1H-imidazo[1,2-a]imidazol-2-one: A Key Intermediate for the Synthesis of LFA-1 Inhibitors-Reference-Cited by-同舟云学术

Development of a Scalable Process for 1-(3,5-Dichlorophenyl)-5-iodo-3-methyl- (4-methylbenzyl)-1H-imidazo[1,2-a]imidazol-2-one: A Key Intermediate for the Synthesis of LFA-1 Inhibitors

Published:2005-01-15 Issue:2 Volume:9 Page:137-140
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Frutos Rogelio P.¹,Eriksson Magnus¹,Wang Xiao-Jun¹,Byrne Denis¹,Varsolona Richard¹,Johnson Michael D.¹,Nummy Lawrence¹,Krishnamurthy Dhileepkumar¹,Senanayake Chris H.¹

Affiliation:

1. Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road/P.O. Box 368, Ridgefield, Connecticut 06877-0368, U.S.A.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op049813o

Reference8 articles.

1. Adhesion receptors of the immune system

2. Self-Regeneration of Stereocenters: A Practical Enantiospecific Synthesis of LFA-1 Antagonist BIRT-377

3. (b) Frutos, R. P.; Stehle, S.; Nummy, L.; Yee, N.Tetrahedron: Asymmetry2001,12, 101.

4. Regiocontrolled synthesis of highly-functionalized fused imidazoles: a novel synthesis of second generation LFA-1 inhibitors

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