The Biosynthesis of Spinosyn in Saccharopolyspora spinosa: Synthesis of the Cross-Bridging Precursor and Identification of the Function of SpnJ-Reference-Cited by-同舟云学术

The Biosynthesis of Spinosyn in Saccharopolyspora spinosa: Synthesis of the Cross-Bridging Precursor and Identification of the Function of SpnJ

Published:2007-11-07 Issue:47 Volume:129 Page:14582-14584
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Kim Hak Joong¹,Pongdee Rongson¹,Wu Qingquan¹,Hong Lin¹,Liu Hung-wen¹

Affiliation:

1. Division of Medicinal Chemistry, College of Pharmacy, and Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, Texas 78712

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja076580i

Reference27 articles.

1. A83543A-D, unique fermentation-derived tetracyclic macrolides

2. Natural products as insecticides: the biology, biochemistry and quantitative structure-activity relationships of spinosyns and spinosoids

3. (b) Salgado, V. L.; Sparks, T. C. InComprehensive MolecularInsect Science; Iatrou, K., Gill, S. S., Gilbert, L. I., Eds.; Pergamon: Oxford, 2005; Vol. 6, pp 137−173.

4. Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa11The DNA sequence reported here was deposited in GenBank under the accession number AY007564.

5. Heterologous expression in Saccharopolyspora erythraea of a pentaketide synthase derived from the spinosyn polyketide synthaseElectronic supplementary information (ESI) available: Further details of the construction of pCJR308, the fermentation of BIOT-0966 and the isolation of pentaketide lactone, 3, and figures showing the13C NMR and 1H COSY spectra of 3. See http://www.rsc.org/suppdata/ob/b3/b310740j/

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