Evidence for an Enzyme-Catalyzed Rauhut–Currier Reaction during the Biosynthesis of Spinosyn A-Reference-Cited by-同舟云学术

Evidence for an Enzyme-Catalyzed Rauhut–Currier Reaction during the Biosynthesis of Spinosyn A

Published:2021-11-23 Issue:48 Volume:143 Page:20291-20295
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Choi Sei-hyun¹,Jeon Byungsun¹,Kim Namho²,Wu Hsin-Hui³,Ko Tzu-Ping³^ORCID,Ruszczycky Mark W.²,Isiorho Eta A.¹,Liu Yung-nan²,Keatinge-Clay Adrian T.⁴,Tsai Ming-Daw³^ORCID,Liu Hung-wen¹²^ORCID

Affiliation:

1. Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States

2. Division of Chemical Biology & Medicinal Chemistry, College of Pharmacy, University of Texas at Austin, Austin, Texas 78712, United States

3. Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan

4. Department of Molecular Biosciences, University of Texas at Austin, Austin, Texas 78712, United States

Funder

Welch Foundation

National Institute of General Medical Sciences

Taiwan Protein Projects

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.1c09482

Reference27 articles.

1. A83543A-D, unique fermentation-derived tetracyclic macrolides

2. The spinosyn family of insecticides: realizing the potential of natural products research

3. Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa11The DNA sequence reported here was deposited in GenBank under the accession number AY007564.

4. Heterologous expression in Saccharopolyspora erythraea of a pentaketide synthase derived from the spinosyn polyketide synthaseElectronic supplementary information (ESI) available: Further details of the construction of pCJR308, the fermentation of BIOT-0966 and the isolation of pentaketide lactone, 3, and figures showing the13C NMR and 1H COSY spectra of 3. See http://www.rsc.org/suppdata/ob/b3/b310740j/

5. Biosynthesis of Structurally Unique Fungal Metabolite GKK1032A2: Indication of Novel Carbocyclic Formation Mechanism in Polyketide Biosynthesis

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