Differential Time-Dependent Inactivation of P450 3A4 and P450 3A5 by Raloxifene: A Key Role for C239 in Quenching Reactive Intermediates-Reference-Cited by-同舟云学术

Differential Time-Dependent Inactivation of P450 3A4 and P450 3A5 by Raloxifene: A Key Role for C239 in Quenching Reactive Intermediates

Published:2007-11-15 Issue:12 Volume:20 Page:1778-1786
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Pearson Josh T.¹,Wahlstrom Jan L.¹,Dickmann Leslie J.¹,Kumar Santosh¹,Halpert James R.¹,Wienkers Larry C.¹,Foti Robert S.¹,Rock Dan A.¹

Affiliation:

1. Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., 1201 Amgen Court West, Seattle, Washington 98119-3105, and Department of Pharmacology and Toxicology, University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555-1031

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx700207u

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3. POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE

4. Hypotensive response to debrisoquine and hydroxylation phenotype

5. CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants

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