New 3-Alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-Dioxide Derivatives Activate ATP-Sensitive Potassium Channels of Pancreatic Beta Cells-Reference-Cited by-同舟云学术

New 3-Alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-Dioxide Derivatives Activate ATP-Sensitive Potassium Channels of Pancreatic Beta Cells

Published:2006-06-13 Issue:14 Volume:49 Page:4127-4139
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Nielsen Flemming E.¹,Ebdrup Søren¹,Jensen Anette Frost¹,Ynddal Lars¹,Bodvarsdottir Thora B.¹,Stidsen Carsten¹,Worsaae Anne¹,Boonen Harrie C. M.¹,Arkhammar Per O. G.¹,Fremming Tinna¹,Wahl Philip¹,Kornø Hanne T.¹,Hansen J. Bondo¹

Affiliation:

1. Novo Nordisk Research and Development, Novo Nordisk Park, DK 2760 Måløv, Denmark

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm060042j

Reference44 articles.

1. Glucose- and Interleukin-1β-Induced β-Cell Apoptosis Requires Ca2+ Influx and Extracellular Signal-Regulated Kinase (ERK) 1/2 Activation and Is Prevented by a Sulfonylurea Receptor 1/Inwardly Rectifying K+ Channel 6.2 (SUR/Kir6.2) Selective Potassium Channel Opener in Human Islets

2. Induction of β-Cell Rest by a Kir6.2/SUR1-Selective KATP-Channel Opener Preserves β-Cell Insulin Stores and Insulin Secretion in Human Islets Cultured at High (11 mM) Glucose

3. Inhibition of Insulin Secretion as a New Drug Target in the Treatment of Metabolic Disorders

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