1. Institute of Molecular Medicine & Department of Life Science, National Tsing Hua University, Hsinchu 300, Taiwan, Republic of China, Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan, Republic of China, Genomics Research Center, Academia Sinica, Taipei 115, Taiwan, Republic of China, and Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County 350, Taiwan, Republic of China