Lead Optimization of 1,4-Azaindoles as Antimycobacterial Agents-Reference-Cited by-同舟云学术

Lead Optimization of 1,4-Azaindoles as Antimycobacterial Agents

Published:2014-06-20 Issue:13 Volume:57 Page:5728-5737
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Shirude Pravin S.¹,Shandil Radha K.²,Manjunatha M. R.¹,Sadler Claire³,Panda Manoranjan¹,Panduga Vijender²,Reddy Jitendar²,Saralaya Ramanatha²,Nanduri Robert²,Ambady Anisha⁴,Ravishankar Sudha⁴,Sambandamurthy Vasan K.⁴,Humnabadkar Vaishali⁴,Jena Lalit K.¹,Suresh Rudrapatna S.¹,Srivastava Abhishek²,Prabhakar K. R.²,Whiteaker James⁵,McLaughlin Robert E.⁵,Sharma Sreevalli⁴,Cooper Christopher B.⁶,Mdluli Khisi⁶,Butler Scott⁵,Iyer Pravin S.¹,Narayanan Shridhar⁴,Chatterji Monalisa⁴

Affiliation:

1. Department of Medicinal Chemistry, iMED Infection, AstraZeneca, Bellary Road, Hebbal, Bangalore 560024, India

2. DMPK and Animal Sciences, iMED Infection, AstraZeneca, Hebbal, Bangalore 560024, India

3. Safety Assessment, iMED, AstraZeneca, Alderly Park, Mereside SK10 4TG, United Kingdom

4. Department of Biosciences, iMED Infection, AstraZeneca, Hebbal, Bangalore 560024, India

5. Infection iMED, AstraZeneca, GHP, Waltham, Massachusetts 02451, United States

6. Global Alliance for TB Drug Development, New York, New York 10005, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm500571f

Reference12 articles.

1. Global Tuberculosis Report 2013;World Health Organization:Geneva, Switzerland, 2013.

2. Scaling up interventions to achieve global tuberculosis control: progress and new developments

3. Azaindoles: Noncovalent DprE1 Inhibitors from Scaffold Morphing Efforts, Kill Mycobacterium tuberculosis and Are Efficacious in Vivo

4. Decaprenylphosphoryl Arabinofuranose, the Donor of the d -Arabinofuranosyl Residues of Mycobacterial Arabinan, Is Formed via a Two-Step Epimerization of Decaprenylphosphoryl Ribose

5. Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis

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