Catalytic Redundancies and Conformational Plasticity Drives Selectivity and Promiscuity in Quorum Quenching Lactonases

Author:

Corbella Marina12ORCID,Bravo Joe3,Demkiv Andrey O.2,Calixto Ana Rita24ORCID,Sompiyachoke Kitty5ORCID,Bergonzi Celine3,Brownless Alfie-Louise R.6,Elias Mikael H.35ORCID,Kamerlin Shina Caroline Lynn26ORCID

Affiliation:

1. Departament de Química Inorgànica (Seeió de Química Orgànica) & Institut de Química Teòrica i Computacional (IQTCUB), Universitat de Barcelona, Martíi Franquès 1, 08028 Barcelona, Spain

2. Department of Chemistry − BMC, Uppsala University, BMC Box 576, S-751 23 Uppsala, Sweden

3. BioTechnology Institute, University of Minnesota, Saint Paul, Minnesota 55108, United States

4. LAQV, REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre, s/n, 4169-007 Porto, Portugal

5. Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Saint Paul, Minnesota 55108, United States

6. School of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive NW, Atlanta, Georgia 30332, United States

Funder

Vetenskapsrådet

Knut och Alice Wallenbergs Stiftelse

Barcelona Supercomputing Center

University of Minnesota

National Institute of General Medical Sciences

Swedish National Infrastructure for Computing

Publisher

American Chemical Society (ACS)

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