Real-Time Evolution of New Genes by Innovation, Amplification, and Divergence-Reference-Cited by-同舟云学术

Real-Time Evolution of New Genes by Innovation, Amplification, and Divergence

Published:2012-10-19 Issue:6105 Volume:338 Page:384-387
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Näsvall Joakim¹,Sun Lei¹,Roth John R.²,Andersson Dan I.¹

Affiliation:

1. Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.

2. Department of Biology, University of California, Davis, CA, USA.

Abstract

Duplicate Gene, New Tricks The fact that functionally new genes appear is clear, but the evolutionary process that allows for a new gain of function is not well understood. Näsvall et al. (p. 384 ) present the innovation-amplification-divergence model which suggests that after gene duplication, ancestral function is maintained but that the duplicate copies can gain new function that is selected for through the accumulation of mutations or changes in expression. Experimental selection on Salmonella enterica allowed an ancestral gene to evolve new enzymatic function in fewer than 3000 generations.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference33 articles.

1. Lateral gene transfer and the nature of bacterial innovation

2. S. Ohno Evolution by Gene Duplication (Springer New York 1970).

3. Duplication Frequency in a Population of Salmonella enterica Rapidly Approaches Steady State With or Without Recombination

4. Evolution of new gene functions: simulation and analysis of the amplification model

5. Ohno's dilemma: Evolution of new genes under continuous selection

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