Structure–Activity Relationships of Peptides Incorporating a Bioactive Reverse-Turn Heterocycle at the Melanocortin Receptors: Identification of a 5800-fold Mouse Melanocortin-3 Receptor (mMC3R) Selective Antagonist/Partial Agonist versus the Mouse Melanocortin-4 Receptor (mMC4R)-Reference-Cited by-同舟云学术

Structure–Activity Relationships of Peptides Incorporating a Bioactive Reverse-Turn Heterocycle at the Melanocortin Receptors: Identification of a 5800-fold Mouse Melanocortin-3 Receptor (mMC3R) Selective Antagonist/Partial Agonist versus the Mouse Melanocortin-4 Receptor (mMC4R)

Published:2013-03-25 Issue:7 Volume:56 Page:2747-2763
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Singh Anamika¹²,Dirain Marvin¹,Witek Rachel¹,Rocca James R.³,Edison Arthur S.⁴,Haskell-Luevano Carrie¹²

Affiliation:

1. Departments of Medicinal Chemistry and Pharmacodynamics, University of Florida, Gainesville, Florida 32610, United States

2. Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States

3. McKnight Brain Institute, University of Florida, Gainesville, Florida 32611, United States

4. Department of Biochemistry & Molecular Biology and National High Magnetic Field Laboratory, University of Florida, Gainesville, Florida 32610, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm301253y

Reference95 articles.

1. Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA

2. The Cloning of a Family of Genes That Encode the Melanocortin Receptors

3. Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system.

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