Effect of Surfactants, Gastric Emptying, and Dosage Form on Supersaturation of Dipyridamole in an in Vitro Model Simulating the Stomach and Duodenum
Author:
Affiliation:
1. Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Butler University, Indianapolis, Indiana 46208, United States
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/mp500196f
Reference51 articles.
1. Drug Supersaturation in Simulated Human Intestinal Fluids Representing Different Nutritional States
2. In Vivo Dog Intestinal Precipitation of Mebendazole: A Basic BCS Class II Drug
3. Ordered mesoporous silica induces pH-independent supersaturation of the basic low solubility compound itraconazole resulting in enhanced transepithelial transport
4. Predicting the precipitation of poorly soluble weak bases upon entry in the small intestine
5. An In Vitro Methodology for Forecasting Luminal Concentrations and Precipitation of Highly Permeable Lipophilic Weak Bases in the Fasted Upper Small Intestine
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