Benzimidazoles: Novel Mycobacterial Gyrase Inhibitors from Scaffold Morphing

Author:

Hameed P Shahul1,Raichurkar Anandkumar1,Madhavapeddi Prashanti1,Menasinakai Sreenivasaiah1,Sharma Sreevalli1,Kaur Parvinder1,Nandishaiah Radha1,Panduga Vijender1,Reddy Jitendar1,Sambandamurthy Vasan K.1,Sriram D.

Affiliation:

1. AstraZeneca India Pvt. Ltd., Avishkar, Bellary Road, Bangalore 560024, India

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference10 articles.

1. World Health Organization. Global tuberculosis control,2012. http://www.who.int/mediacentre/news/releases/2011/tb_20111011/en/index.html.

2. World Health Organization. Multidrug and extensively drug-resistantTB (M/XDR-TB); WHO 2010global report on surveillance and response.

3. Non-quinolone Inhibitors of Bacterial Type IIA Topoisomerases: A Feat of Bioisosterism

4. Novel N-Linked Aminopiperidine-Based Gyrase Inhibitors with Improved hERG and in Vivo Efficacy against Mycobacterium tuberculosis

5. Beijing Genotype of Mycobacterium tuberculosis Is Significantly Associated with High-Level Fluoroquinolone Resistance in Vietnam

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