Novel Tetrahydropyrido[1,2-a]isoindolone Derivatives (Valmerins): Potent Cyclin-Dependent Kinase/Glycogen Synthase Kinase 3 Inhibitors with Antiproliferative Activities and Antitumor Effects in Human Tumor Xenografts-Reference-Cited by-同舟云学术

Novel Tetrahydropyrido[1,2-a]isoindolone Derivatives (Valmerins): Potent Cyclin-Dependent Kinase/Glycogen Synthase Kinase 3 Inhibitors with Antiproliferative Activities and Antitumor Effects in Human Tumor Xenografts

Published:2012-11-01 Issue:22 Volume:55 Page:9589-9606
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Boulahjar Rajâa¹²,Ouach Aziz¹,Matteo Chiurato¹,Bourg Stephane¹,Ravache Myriam³,Guével Rémy le³,Marionneau Séverine⁴,Oullier Thibauld⁴,Lozach Olivier⁵,Meijer Laurent⁵⁶,Guguen-Guillouzo Christiane³,Lazar Saïd²,Akssira Mohamed²,Troin Yves⁷,Guillaumet Gérald¹,Routier Sylvain¹

Affiliation:

1. Institut de Chimie Organique et Analytique, Université d’Orléans, UMR CNRS 7311, rue de Chartres, BP 6759, 45067 Orléans Cedex 2, France

2. Laboratoire de Chimie, Bioorganique et Analytique, URAC 22 pôle Répam, Université Hassan II Mohammedia-Casablanca, BP 146, 28800 Mohammedia, Morocco

3. Plateforme ImPACcell-SFR BIOSIT UMS-CNRS3480 UMS-INSERM018, Université de Rennes 1, 35043 Rennes Cedex, France.

4. In vivo Platform, Cancéropôle Grand Ouest, 63 quai Magellan, 44000 Nantes, France

5. CNRS, “Protein Phosphorylation & Human Disease” group, USR3151, Station Biologique, B.P. 74, 29682 Roscoff Cedex, France

6. ManRos Therapeutics, Centre de Perharidy, 29680 Roscoff, France

7. Clermont Université, ENSCCF, Laboratoire de Chimie des Hétérocycles et des Glucides, BP 10448, 63000 Clermont-Ferrand, France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm3008536

Reference46 articles.

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