Affiliation:
1. Department of Chemistry Indian Institute of Technology Bombay Powai, Mumbai 400076 India
Abstract
AbstractAn efficient, acid‐mediated, intramolecular alkyne iminium ion cyclization of oxoisoindolidene for the diastereoselective synthesis of pyrrolo/pyridoisoindole is described. This protocol features broad substrate scope and easy scalability. An unusual N to C‐1,3‐alkyl shift is observed with substrates bearing strong electron donating group at the phenyl ring attached to alkyne with concomitant hydration of alkyne to the ketone.
Subject
General Chemistry,Biochemistry,Organic Chemistry