Ranking the Susceptibility of Disulfide Bonds in Human IgG1 Antibodies by Reduction, Differential Alkylation, and LC−MS Analysis
Author:
Affiliation:
1. Process Sciences Department, 100 Research Drive, Abbott Bioresearch Center, Worcester, Massachusetts 01605
Publisher
American Chemical Society (ACS)
Subject
Analytical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ac100575n
Reference34 articles.
1. Identification and Localization of Unpaired Cysteine Residues in Monoclonal Antibodies by Fluorescence Labeling and Mass Spectrometry
2. Localization and Quantitation of Free Sulfhydryl in Recombinant Monoclonal Antibodies by Differential Labeling with 12C and 13C Iodoacetic Acid and LC−MS Analysis
3. The inter-heavy chain disulfide bonds of IgG4 are in equilibrium with intra-chain disulfide bonds
4. Intrachain disulfide bond in the core hinge region of human IgG4
5. Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo
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