Synthesis and Histone Deacetylase Inhibitory Activity of Largazole Analogs: Alteration of the Zinc-Binding Domain and Macrocyclic Scaffold-Reference-Cited by-同舟云学术

Synthesis and Histone Deacetylase Inhibitory Activity of Largazole Analogs: Alteration of the Zinc-Binding Domain and Macrocyclic Scaffold

Published:2009-02-24 Issue:6 Volume:11 Page:1301-1304
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Bowers Albert A.¹,West Nathan¹,Newkirk Tenaya L.¹,Troutman-Youngman Annie E.¹,Schreiber Stuart L.¹,Wiest Olaf¹,Bradner James E.¹,Williams Robert M.¹

Affiliation:

1. Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, University of Colorado Cancer Center, Aurora, Colorado 80045, Division of Hematologic Neoplasia, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, Chemical Biology Program, Broad Institute of Harvard & MIT, Cambridge, Massachusetts 02142, Howard Hughes Medical Institute, Chemistry & Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, and Walther Cancer Research Center and Department of Chemistry...

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ol900078k

Reference38 articles.

1. Histone deacetylase inhibitors – a new tool to treat cancer

2. Synthesis of 7200 Small Molecules Based on a Substructural Analysis of the Histone Deacetylase Inhibitors Trichostatin and Trapoxin

3. Histone Deacetylase Inhibitors: Latest Developments, Trends and Prospects

4. Anticancer activities of histone deacetylase inhibitors

5. A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

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