The Different Flexibility of c-Src and c-Abl Kinases Regulates the Accessibility of a Druggable Inactive Conformation-Reference-Cited by-同舟云学术

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The Different Flexibility of c-Src and c-Abl Kinases Regulates the Accessibility of a Druggable Inactive Conformation

Published:2012-01-30 Issue:5 Volume:134 Page:2496-2499
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Lovera Silvia¹,Sutto Ludovico¹,Boubeva Ralitza²,Scapozza Leonardo²,Dölker Nicole¹,Gervasio Francesco L.¹

Affiliation:

1. Structural Biology and Biocomputing Programme, Spanish National Cancer Research Center (CNIO), Melchor Fernandez Almagro 3, E-28029 Madrid, Spain

2. Pharmaceutical Biochemistry, School of Pharmaceutical Sciences, University of Geneva, Quai Ernest-Ansermet 30, 1211 Genève 4, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja210751t

Reference24 articles.

1. The Protein Kinase Complement of the Human Genome

2. Protein Kinase Inhibitors: Insights into Drug Design from Structure

3. Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug

4. Regulation of the c-Abl and Bcr–Abl tyrosine kinases

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