Allosteric enhancement of the BCR-Abl1 kinase inhibition activity of nilotinib by cobinding of asciminib

Author:

Oruganti Baswanth,Lindahl Erik,Yang Jingmei,Amiri Wahid,Rahimullah RezwanORCID,Friedman RanORCID

Funder

Cancerfonden

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference73 articles.

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2. Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia;Shah;Cancer Cell,2002

3. Characterization of AMN107, A selective inhibitor of native and mutant bcr-Abl;Weisberg;Cancer Cell,2005

4. Overriding imatinib resistance with a novel ABL kinase inhibitor;Shah;Science,2004

5. SKI-606, a 4-Anilino-3-quinolinecarbonitrile dual inhibitor of src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice;Golas;Cancer Res.,2003

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