Mechanism-Based Inactivation of Cytochrome P450 2B1 by 7-Ethynylcoumarin: Verification of Apo-P450 Adduction by Electrospray Ion Trap Mass Spectrometry-Reference-Cited by-同舟云学术

Mechanism-Based Inactivation of Cytochrome P450 2B1 by 7-Ethynylcoumarin: Verification of Apo-P450 Adduction by Electrospray Ion Trap Mass Spectrometry

Published:2000-03-21 Issue:4 Volume:13 Page:262-270
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Regal Kelly A.¹,Schrag Michael L.¹,Kent Ute M.¹,Wienkers Larry C.¹,Hollenberg Paul F.¹

Affiliation:

1. Department of Pharmacology, The University of Michigan, Ann Arbor, Michigan 48109, and Drug Metabolism Research, Pharmacia & Upjohn, Inc., Kalamazoo, Michigan 49007

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx990195s

Reference64 articles.

1. Fraser, D. J., He, Y. Q., Harlow, G. R., and Halpert, J. R. (1999) Use of chimeric enzymes and site-directed mutagenesis for identification of three key residues responsible for differences in steroid hydroxylation between canine cytochromes P-450 3A12 and 3A26.Mol. Pharmacol.55, 241−247.

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