Simple Secondary Amines Inhibit Growth of Gram-Negative Bacteria through Highly Selective Binding to Phenylalanyl-tRNA Synthetase
Author:
Affiliation:
1. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States
2. Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States
Funder
Harvard University
National Institute of Allergy and Infectious Diseases
Publisher
American Chemical Society (ACS)
Subject
Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis
Link
https://pubs.acs.org/doi/pdf/10.1021/jacs.0c11113
Reference18 articles.
1. Molecular Basis of Bacterial Outer Membrane Permeability Revisited
2. Permeability Barrier of Gram-Negative Cell Envelopes and Approaches To Bypass It
3. Predictive compound accumulation rules yield a broad-spectrum antibiotic
4. Antibiotics and Bacterial Resistance in the 21st Century
5. Treatment of infections caused by multidrug-resistant Gram-negative bacteria: report of the British Society for Antimicrobial Chemotherapy/Healthcare Infection Society/British Infection Association Joint Working Party†
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