Identification and Optimization of Pteridinone Toll-like Receptor 7 (TLR7) Agonists for the Oral Treatment of Viral Hepatitis-Reference-Cited by-同舟云学术

Identification and Optimization of Pteridinone Toll-like Receptor 7 (TLR7) Agonists for the Oral Treatment of Viral Hepatitis

Published:2013-09-09 Issue:18 Volume:56 Page:7324-7333
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Roethle Paul A.¹,McFadden Ryan M.¹,Yang Hong¹,Hrvatin Paul¹,Hui Hon¹,Graupe Michael¹,Gallagher Brian¹,Chao Jessica¹,Hesselgesser Joseph¹,Duatschek Paul¹,Zheng Jim¹,Lu Bing¹,Tumas Daniel B.¹,Perry Jason¹,Halcomb Randall L.¹

Affiliation:

1. Departments of †Medicinal Chemistry, ‡Clinical Virology, §Drug Metabolism, ∥Biology, and ⊥Structural Chemistry, Gilead Sciences, 333 Lakeside Drive, Foster City, California 94404, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm400815m

Reference62 articles.

1. Toll-like receptors: critical proteins linking innate and acquired immunity

2. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

3. Innate Immune Recognition

4. Toll-Like Receptors

5. Inferences, questions and possibilities in Toll-like receptor signalling

Cited by 63 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Design, Synthesis, and Biological Evaluation of New 2,6,7-Substituted Purine Derivatives as Toll-like Receptor 7 Agonists for Intranasal Vaccine Adjuvants;Journal of Medicinal Chemistry;2024-05-24

2. Structure–Activity Relationships toward the Identification of a High-Potency Selective Human Toll-like Receptor-7 Agonist;Journal of Medicinal Chemistry;2024-05-14

3. Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology;ACS Medicinal Chemistry Letters;2024-01-09

4. Discovery of Novel TLR7 Agonists as Systemic Agent for Combination With aPD1 for Use in Immuno-oncology;ACS Medicinal Chemistry Letters;2024-01-08

5. Structural Optimization and Biological Evaluation of Isoxazolo[5,4-d]pyrimidines as Selective Toll-Like Receptor 7 Agonists;ACS Omega;2024-01-04