1. Department of Experimental Medicine, Second University of Naples, Via S. M. di Costantinopoli, 16, 80138 Naples, Italy, National Institute of Biosystems and Biostructures (INBB), Viale Medaglie d’Oro, 305, 00136 Rome, Italy, Institute of Genetic and Biophysics “ABT”, Via P. Castellino, 111, 80131 Naples, Italy, Department of Biotechnology, University “Prof. Dr. A. Zlatarov”, Bourgas 8010, Bulgaria, and Department of Pharmacobiology, University of Messina, Via SS Annunziata, 90168, Messina, Italy