Selective Benzopyranone and Pyrimido[2,1-a]isoquinolin-4-one Inhibitors of DNA-Dependent Protein Kinase: Synthesis, Structure−Activity Studies, and Radiosensitization of a Human Tumor Cell Line in Vitro-Reference-Cited by-同舟云学术

Selective Benzopyranone and Pyrimido[2,1-a]isoquinolin-4-one Inhibitors of DNA-Dependent Protein Kinase: Synthesis, Structure−Activity Studies, and Radiosensitization of a Human Tumor Cell Line in Vitro

Published:2004-12-29 Issue:2 Volume:48 Page:569-585
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Griffin Roger J.¹,Fontana Gabriele¹,Golding Bernard T.¹,Guiard Sophie¹,Hardcastle Ian R.¹,Leahy Justin J. J.¹,Martin Niall¹,Richardson Caroline¹,Rigoreau Laurent¹,Stockley Martin¹,Smith Graeme C. M.¹

Affiliation:

1. Northern Institute for Cancer Research, School of Natural SciencesChemistry, Bedson Building, The University, Newcastle upon Tyne NE1 7RU, U.K., and KuDOS Pharmaceuticals Ltd., 327 Cambridge Science Park, Milton Road, Cambridge CB4 0WG, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm049526a

Reference40 articles.

1. DNA Repair: Enzymatic Mechanisms and Relevance to Drug Response

2. Sensing and repairing DNA double-strand breaks

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