Cardiovascular Characterization of Pyrrolo[2,1-d][1,5]benzothiazepine Derivatives Binding Selectively to the Peripheral-Type Benzodiazepine Receptor (PBR): From Dual PBR Affinity and Calcium Antagonist Activity to Novel and Selective Calcium Entry Blockers-Reference-Cited by-同舟云学术

Cardiovascular Characterization of Pyrrolo[2,1-d][1,5]benzothiazepine Derivatives Binding Selectively to the Peripheral-Type Benzodiazepine Receptor (PBR): From Dual PBR Affinity and Calcium Antagonist Activity to Novel and Selective Calcium Entry Blockers

Published:1996-01-01 Issue:15 Volume:39 Page:2922-2938
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Campiani Giuseppe¹,Fiorini Isabella¹,De Filippis Maria P.¹,Ciani Silvia M.¹,Garofalo Antonio¹,Nacci Vito¹,Giorgi Gianluca¹,Sega Alessandro¹,Botta Maurizio¹,Chiarini Alberto¹,Budriesi Roberta¹,Bruni Giancarlo¹,Romeo Maria R.¹,Manzoni Cristina¹,Mennini Tiziana¹

Affiliation:

1. Dipartimento Farmaco Chimico Tecnologico, Banchi di Sotto 55, Istituto di Farmacologia, Via delle Scotte 6, Istituto di Chimica Organica, Pian dei Mantellini, and Centro Interdipartimentale di Analisi e Determinazioni Strutturali, Via Mattioli 10, Universita' di Siena, 53100 Siena, Italy, Dipartimento di Scienze Farmaceutiche, Via Belmeloro 6, Universita' di Bologna, 40126 Bologna, Italy, and Istituto di Ricerche Farmacologiche “Mario Negri”, Via Eritrea 62, 20127 Milano, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm960162z

Reference71 articles.

1. Interaction of benzodiazepines with mouse macrophages

2. Electrophysiological and pharmacological characterization of peripheral benzodiazepine receptors in a guinea pig heart preparation

3. Benzodiazepine Ro 5-4864 increases coronary flow

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