Affiliation:
1. SynBioC Research Group Department of Green Chemistry and Technology Faculty of Bioscience Engineering Ghent University Coupure Links 653 Ghent 9000 Belgium
2. Department of Food Technology, Safety and Health Ghent University Coupure Links 653 Ghent 9000 Belgium
Abstract
AbstractThe 1,5‐benzothiazepane structure is an important heterocyclic moiety present in a variety of commercial drugs and pharmaceuticals. This privileged scaffold exhibits a diversity of biological activities, including antimicrobial, antibacterial, anti‐epileptic, anti‐HIV, antidepressant, antithrombotic and anticancer properties. Its important pharmacological potential renders research into the development of new and efficient synthetic methods of high relevance. In the first part of this review, an overview of different synthetic approaches toward 1,5‐benzothiazepane and its derivatives is provided, ranging from established protocols to recent (enantioselective) methods that promote sustainability. In the second part, several structural characteristics influencing biological activity are briefly explored, providing a few insights into the structure‐activity relationships of these compounds.