Binding of 13-Amidohuprines to Acetylcholinesterase: Exploring the Ligand-Induced Conformational Change of the Gly117-Gly118 Peptide Bond in the Oxyanion Hole-Reference-Cited by-同舟云学术

Binding of 13-Amidohuprines to Acetylcholinesterase: Exploring the Ligand-Induced Conformational Change of the Gly117-Gly118 Peptide Bond in the Oxyanion Hole

Published:2006-10-19 Issue:23 Volume:49 Page:6833-6840
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Camps Pelayo¹,Gómez Elena¹,Muñoz-Torrero Diego¹,Badia Albert¹,Clos Maria Victòria¹,Curutchet Carles¹,Muñoz-Muriedas Jordi¹,Luque Francisco Javier¹

Affiliation:

1. Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia, Universitat de Barcelona, Av. Diagonal 643, E-08028, Barcelona, Spain, Departament de Farmacologia, de Terapèutica i de Toxicologia, Facultat de Medicina, Universitat Autònoma de Barcelona, E-08193-Bellaterra, Barcelona, Spain, and Departament de Fisicoquímica, Facultat de Farmàcia, Universitat de Barcelona, Av. Diagonal 643, E-08028, Barcelona, Spain

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm060945c

Reference44 articles.

1. Synthesis and evaluation of tacrine–Huperzine a hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of alzheimer’s disease

2. Synthesis, in Vitro Pharmacology, and Molecular Modeling of Very Potent Tacrine−Huperzine A Hybrids as Acetylcholinesterase Inhibitors of Potential Interest for the Treatment of Alzheimer's Disease

3. New Tacrine−Huperzine A Hybrids (Huprines): Highly Potent Tight-Binding Acetylcholinesterase Inhibitors of Interest for the Treatment of Alzheimer's Disease

4. Tacrine-Huperzine A Hybrids (Huprines) A New Class of Highly Potent and Selective Acetylcholinesterase Inhibitors of Interest for the Treatment of Alzheimer Disease

Cited by 18 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Acetylcholinesterase: A Versatile Template to Coin Potent Modulators of Multiple Therapeutic Targets;Accounts of Chemical Research;2024-02-09

2. Identifying Possible AChE Inhibitors from Drug-like Molecules via Machine Learning and Experimental Studies;ACS Omega;2022-06-08

3. Huprines — an insight into the synthesis and biological properties;Russian Chemical Reviews;2020-10-01

4. Discovery of Novel Acetylcholinesterase Inhibitors as Potential Candidates for the Treatment of Alzheimer’s Disease;International Journal of Molecular Sciences;2019-02-25

5. Binding free energy calculations to rationalize the interactions of huprines with acetylcholinesterase;Journal of Computer-Aided Molecular Design;2018-03-26