Insights into the Novel Hydrolytic Mechanism of a Diethyl 2-Phenyl-2-(2-arylacetoxy)methyl Malonate Ester-Based Microsomal Triglyceride Transfer Protein (MTP) Inhibitor-Reference-Cited by-同舟云学术

Insights into the Novel Hydrolytic Mechanism of a Diethyl 2-Phenyl-2-(2-arylacetoxy)methyl Malonate Ester-Based Microsomal Triglyceride Transfer Protein (MTP) Inhibitor

Published:2012-09-27 Issue:10 Volume:25 Page:2138-2152
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Ryder Tim¹,Walker Gregory S.¹,Goosen Theunis C.¹,Ruggeri Roger B.²,Conn Edward L.³,Rocke Benjamin N.³,Lapham Kimberly¹,Steppan Claire M.¹,Hepworth David²,Kalgutkar Amit S.⁴

Affiliation:

1. Pharmacokinetics, Dynamics, and Metabolism−New Chemical Entities, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States

2. Cardiovascular Metabolic and Endocrine Diseases Medicinal Chemistry, Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States

3. Cardiovascular Metabolic and Endocrine Diseases Medicinal Chemistry, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States

4. Pharmacokinetics, Dynamics, and Metabolism−New Chemical Entities, Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx300243v

Reference39 articles.

1. Microsomal Triglyceride Transfer Protein

2. MTP inhibition as a treatment for dyslipidaemias: time to deliver or empty promises?

3. Absence of Microsomal Triglyceride Transfer Protein in Individuals with Abetalipoproteinemia

4. Cloning and gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinaemia

5. Abetalipoproteinemia

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