Determination of Antibody–Drug Conjugate Released Payload Species Using Directed in Vitro Assays and Mass Spectrometric Interrogation-Reference-Cited by-同舟云学术

Determination of Antibody–Drug Conjugate Released Payload Species Using Directed in Vitro Assays and Mass Spectrometric Interrogation

Published:2016-06-13 Issue:7 Volume:27 Page:1645-1654
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

Bessire Andrew J.¹²³,Ballard T. Eric¹²³,Charati Manoj¹²³,Cohen Justin¹²³,Green Michael¹²³,Lam My-Hanh¹²³,Loganzo Frank¹²³,Nolting Birte¹²³,Pierce Betsy¹²³,Puthenveetil Sujiet¹²³,Roberts Lee¹²³,Schildknegt Klaas¹²³,Subramanyam Chakrapani¹²³

Affiliation:

1. Pharmacokinetics, Dynamics and Metabolism, ∥Worldwide Medicinal Chemistry, and ¶Pharmaceutical Sciences Chemical R&D, Pfizer Worldwide R&D, Groton, Connecticut 06340, United States

2. Oncology Research Unit, and ⊥Bioprocess R&D, Pfizer Worldwide R&D, Pearl River, New York 10965, United States

3. Worldwide Medicinal Chemistry, and §Global Biotherapeutics Technologies, Pfizer Worldwide R&D, Cambridge, Massachusetts 02139, United States

Funder

Pfizer

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.6b00192

Reference41 articles.

1. Field Guide to Challenges and Opportunities in Antibody–Drug Conjugates for Chemists