Fragment-Based Discovery of Bromodomain Inhibitors Part 2: Optimization of Phenylisoxazole Sulfonamides-Reference-Cited by-同舟云学术

Fragment-Based Discovery of Bromodomain Inhibitors Part 2: Optimization of Phenylisoxazole Sulfonamides

Published:2012-01-11 Issue:2 Volume:55 Page:587-596
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bamborough Paul¹,Diallo Hawa²,Goodacre Jonathan D.²,Gordon Laurie³,Lewis Antonia³,Seal Jonathan T.²,Wilson David M.²,Woodrow Michael D.²,Chung Chun-wa¹

Affiliation:

1. Computational & Structural Chemistry, Molecular Discovery Research, GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.

2. Epinova DPU, Immuno-Inflammation Centre of Excellence for Drug Discovery, GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.

3. Screening & Compound Profiling, Molecular Discovery Research, GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm201283q

Reference24 articles.

1. An emerging role for bromodomain-containing proteins in chromatin regulation and transcriptional control of adipogenesis

2. Suppression of inflammation by a synthetic histone mimic

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