Total Synthesis of the Potent and Broad-Spectrum Antibiotics Amycolamicin and Kibdelomycin
Author:
Affiliation:
1. National Institute of Biological Sciences, Beijing, 102206, China
2. Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, 100084, China
Funder
Ministry of Science and Technology of the People's Republic of China
Beijing Municipal Science and Technology Commission
Tsinghua University
Publisher
American Chemical Society (ACS)
Subject
Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis
Link
https://pubs.acs.org/doi/pdf/10.1021/jacs.1c11477
Reference46 articles.
1. Towards the sustainable discovery and development of new antibiotics
2. Igarashi, M.; Sawa, R.; Homma, Y. Novel Compound Amycolamicin, Method for Production Thereof, and Use Thereof. Jpn Patent JP2009/058210, 2009; WO2010122669A1, 2010.
3. Biosynthesis of amycolamicin: the biosynthetic origin of a branched α-aminoethyl moiety in the unusual sugar amycolose
4. Amycolamicin: A Novel Broad-Spectrum Antibiotic Inhibiting Bacterial Topoisomerase
5. Discovery of Kibdelomycin, A Potent New Class of Bacterial Type II Topoisomerase Inhibitor by Chemical-Genetic Profiling in Staphylococcus aureus
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