Formal synthesis of kibdelomycin and derivatisation of amycolose glycosides-Reference-Cited by-同舟云学术

Formal synthesis of kibdelomycin and derivatisation of amycolose glycosides

Published:2023 Issue:13 Volume:14 Page:3562-3568
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Schriefer Manuel G.¹,Treiber Laura¹,Schobert Rainer¹^ORCID

Affiliation:

1. Organic chemistry laboratory, University of Bayreuth, Universitaetsstr. 30, 95447 Bayreuth, Germany

Abstract

A new formal synthesis gave kibdelomycin with 2.8% yield over 19 steps, featuring a general method for introduction of a 3-(α-aminoalkyl) linkage into glycosides, and the firstN-glycosylation of 3-acyltetramic acids.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC00595J

Reference28 articles.

1. Biosynthesis of amycolamicin: the biosynthetic origin of a branched α-aminoethyl moiety in the unusual sugar amycolose

2. Discovery of Kibdelomycin, A Potent New Class of Bacterial Type II Topoisomerase Inhibitor by Chemical-Genetic Profiling in Staphylococcus aureus

3. Amycolamicin: A Novel Broad-Spectrum Antibiotic Inhibiting Bacterial Topoisomerase

4. Structures of Kibdelomycin Bound to Staphylococcus aureus GyrB and ParE Showed a Novel U-Shaped Binding Mode

5. Tetramic and tetronic acids: An update on new derivatives and biological aspects

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