Backbone Hydrocarbon-Constrained Nucleic Acids Modulate Hybridization Kinetics for RNA-Reference-Cited by-同舟云学术

Backbone Hydrocarbon-Constrained Nucleic Acids Modulate Hybridization Kinetics for RNA

Published:2022-01-18 Issue:4 Volume:144 Page:1941-1950
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Rajasekaran Tamilselvan¹,Freestone Graeme C.²,Galindo-Murillo Rodrigo³^ORCID,Lugato Barbara¹,Rico Lorena¹,Salinas Juan C.¹,Gaus Hans²,Migawa Michael T.²,Swayze Eric E.²,Cheatham Thomas E.³^ORCID,Hanessian Stephen¹^ORCID,Seth Punit P.²^ORCID

Affiliation:

1. Department of Chemistry, Université de Montréal, Quebec H3C 3J7, Canada

2. Department of Medicinal Chemistry, Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, California 92010, United States

3. Department of Medicinal Chemistry, College of Pharmacy, University of Utah, 2000 East 30 South Skaggs 201, Salt Lake City, Utah 84112, United States

Funder

Ionis Pharmaceuticals

Natural Sciences and Engineering Research Council of Canada

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.1c12323

Reference45 articles.

1. RNA-Targeted Therapeutics

2. Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs