Towards combining backbone and sugar constraint in 3′-3′ bis-phosphonate tethered 2′-4′ bridged LNA oligonucleotide trimers-Reference-Cited by-同舟云学术

登录注册会员服务联系我们

Towards combining backbone and sugar constraint in 3′-3′ bis-phosphonate tethered 2′-4′ bridged LNA oligonucleotide trimers

Published:2024 Issue:33 Volume:14 Page:23583-23591
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Duchamp Edouard¹,Vasquez Guillermo²,Firoozi Neda¹,Freestone Graeme C.²,Oestergaard Michael²,Seth Punit P.³,Hanessian Stephen¹⁴^ORCID

Affiliation:

1. Department of Chemistry, Université de Montréal, Québec, H3C 3J7, Canada

2. Department of Medicinal Chemistry, Ionis Pharmaceuticals, Carlsbad, CA 92010, USA

3. Alnylam Pharmaceuticals, 675 West Kendall St, Cambridge, MA 0214, USA

4. Department of Pharmaceutical Sciences, University of California, Irvine, CA 92697, USA

Abstract

The synthesis of alkylphosphonate-linked locked nucleic acid (LNA) trimers which restrict conformation of the furanose sugar and conformational mobility of the sugar-phosphate backbone across three nucleotide units is described.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA04277H

Reference32 articles.

1. Antisense technology: an overview and prospectus

2. The current state and future directions of RNAi-based therapeutics

3. Progress in Antisense Oligonucleotide Therapeutics

4. Splice-switching antisense oligonucleotides as therapeutic drugs

5. RNA editing: Expanding the potential of RNA therapeutics

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370

www.globalauthorid.com

TOP