Origins of the Increased Affinity of Phosphorothioate-Modified Therapeutic Nucleic Acids for Proteins-Reference-Cited by-同舟云学术

Origins of the Increased Affinity of Phosphorothioate-Modified Therapeutic Nucleic Acids for Proteins

Published:2020-03-23 Issue:16 Volume:142 Page:7456-7468
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Hyjek-Składanowska Malwina¹²,Vickers Timothy A.³,Napiórkowska Agnieszka¹²,Anderson Brooke A.³,Tanowitz Michael³,Crooke Stanley T.³,Liang Xue-hai³,Seth Punit P.³,Nowotny Marcin¹²^ORCID

Affiliation:

1. Structural Biology Center, International Institute of Molecular and Cell Biology, 4 Trojdena St., 02-109 Warsaw, Poland

2. Laboratory of Protein Structure, International Institute of Molecular and Cell Biology, 4 Trojdena Street, 02-109 Warsaw, Poland

3. Ionis Pharmaceuticals, Inc., 2855 Gazelle Court, Carlsbad, California 92010, United States

Funder

Ionis Pharmaceuticals

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.9b13524

Reference51 articles.

1. The Medicinal Chemistry of Therapeutic Oligonucleotides

2. RNA-Targeted Therapeutics

3. Phosphorothioates, Essential Components of Therapeutic Oligonucleotides

4. Characterization of the interactions of chemically-modified therapeutic nucleic acids with plasma proteins using a fluorescence polarization assay

5. Selective tissue targeting of synthetic nucleic acid drugs

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