A Calicheamicin Conjugate with a Fully Humanized Anti-MUC1 Antibody Shows Potent Antitumor Effects in Breast and Ovarian Tumor Xenografts

Author:

Hamann Philip R.1,Hinman Lois M.1,Beyer Carl F.1,Lindh Delores1,Upeslacis Janis1,Shochat Dan1,Mountain Andrew1

Affiliation:

1. Wyeth Research, 401 N. Middletown Road, Pearl River, New York 10965 and Celltech R & D, 216 Bath Road, Slough, England, SL1-4EN

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Reference29 articles.

1. Aboud-Pirak, E., Sergent, T., Otte-Slachmuylder, C., Abarca, J., Trouet, A., and Schneider, Y.J. (1988) Binding and endocytosis of a monoclonal antibody to a high molecular weight human milk fat globule membrane-associated antigen by cultured MCF-7 breast cancer cells.Cancer Res. 48, 3188−3196.

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