Conformer- and Alignment-Independent Model for Predicting Structurally Diverse Competitive CYP2C9 Inhibitors-Reference-Cited by-同舟云学术

Conformer- and Alignment-Independent Model for Predicting Structurally Diverse Competitive CYP2C9 Inhibitors

Published:2004-01-13 Issue:4 Volume:47 Page:907-914
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Afzelius Lovisa¹,Zamora Ismael¹,Masimirembwa Collen M.¹,Karlén Anders¹,Andersson Tommy B.¹,Mecucci Silvio¹,Baroni Massimo¹,Cruciani Gabriele¹

Affiliation:

1. DMPK and Bioanalytical Chemistry, AstraZeneca R&D, S-431 83 Mölndal, Sweden, Department of Organic Pharmaceutical Chemistry, Uppsala University, Post Office Box 574, S-751 23 Uppsala, Sweden, Lead Molecular Design, Valles 96-102, Loc 27, 08190 Sant Cugat de Valles, Barcelona, Spain, and Laboratory for Chemometrics, Universitá degli Studi di Perugia, Via Elce di Sotto, 12 I-06100 Perugia, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm030972s

Reference24 articles.

1. Competitive CYP2C9 Inhibitors: Enzyme Inhibition Studies, Protein Homology Modeling, and Three-Dimensional Quantitative Structure-Activity Relationship Analysis

2. Novel Approach To Predicting P450-Mediated Drug Metabolism: Development of a Combined Protein and Pharmacophore Model for CYP2D6

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