Discovery of a novel binding pocket for CYP 2C9 inhibitors: crystallography, pharmacophore modelling and inhibitor SAR
Author:
Affiliation:
1. Pfizer Neusentis
2. The Portway Building
3. Cambridge
4. UK
Abstract
CYP 2C9 co-crystal structures of compound1(green) in binding mode 1 (CYP 2C9 in green) and compound2(yellow) in binding mode 2 (CYP 2C9 in yellow).
Publisher
Royal Society of Chemistry (RSC)
Subject
Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/MD/C6MD00011H
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