Structurally Simple Inhibitors of Lanosterol 14α-Demethylase Are Efficacious In a Rodent Model of Acute Chagas Disease-Reference-Cited by-同舟云学术

Structurally Simple Inhibitors of Lanosterol 14α-Demethylase Are Efficacious In a Rodent Model of Acute Chagas Disease

Published:2009-05-22 Issue:12 Volume:52 Page:3703-3715
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Suryadevara Praveen Kumar¹,Olepu Srinivas¹,Lockman Jeffrey W.¹,Ohkanda Junko¹,Karimi Mandana¹,Verlinde Christophe L. M. J.¹,Kraus James M.¹,Schoepe Jan¹,Van Voorhis Wesley C.¹,Hamilton Andrew D.¹,Buckner Frederick S.¹,Gelb Michael H.¹

Affiliation:

1. Departments of Chemistry, Biochemistry, and Medicine, University of Washington, Seattle, Washington 98195, Department of Chemistry, Yale University, New Haven, Connecticut 06520

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm900030h

Reference30 articles.

1. World Health Organization Control of Chagas Disease: Second Report of the Expert Committee;World Health Organization, Technical Report Series;World Health Organization:Geneva, 2002; p905.

2. Buckner, F. S. Van Voorhis. W. C.Immune response to Trypanosoma cruzi: Control of Infection and Pathogenesis of Chagas Disease. Ed;Cunningham, M. W., Fujinami, R. S., Eds.Lippincott Williams & Wilkins:Philadelphia, 2000; Vol. 569, p591.

3. Specific chemotherapy of Chagas disease: controversies and advances

4. The activity of ketoconazole and other azoles against Trypanosoma cruzi: biochemistry and chemotherapeutic action in vitro

5. The Anti- Trypanosoma cruzi Activity of Posaconazole in a Murine Model of Acute Chagas' Disease Is Less Dependent on Gamma Interferon than That of Benznidazole

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