Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase-Reference-Cited by-同舟云学术

Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase

Published:2022-10-11 Issue:20 Volume:65 Page:13753-13770
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wang You¹,Xu Feng²,Nichols Connie B.³⁴^ORCID,Shi Yuqian¹,Hellinga Homme W.¹^ORCID,Alspaugh J. Andrew³⁴,Distefano Mark D.²^ORCID,Beese Lorena S.¹^ORCID

Affiliation:

1. Department of Biochemistry, Duke University School of Medicine, Durham, North Carolina27710, United States

2. Department of Chemistry, University of Minnesota, Minneapolis, Minnesota55455, United States

3. Department of Medicine, Duke University School of Medicine, Durham, North Carolina27710, United States

4. Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina27710, United States

Funder

National Institute of Allergy and Infectious Diseases

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00902

Reference54 articles.

1. The Still Underestimated Problem of Fungal Diseases Worldwide

2. Treatment strategies for cryptococcal infection: challenges, advances and future outlook

3. Common invasive fungal diseases: an overview of invasive candidiasis, aspergillosis, cryptococcosis, and Pneumocystis pneumonia

4. A titanic drug resistance threat in Cryptococcus neoformans

5. Antifungal drug resistance: evolution, mechanisms and impact

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